While Tom's very good at science, his brother is absolutely hopeless.
湯姆很擅長(zhǎng)理科，而他的兄弟絕對(duì)是不可救藥。
This case is hopeless and he knows it.
這個(gè)案子毫無(wú)希望，這一點(diǎn)他是清楚的。
He's a hopeless case.
他是無(wú)可救藥了。
I'm hopeless at science.
我對(duì)理科一竅不通。
Our cat is hopeless at catching mice.
我們的貓絕對(duì)捉不到老鼠。
She felt lonely and hopeless.
她感到孤獨(dú)絕望。